Retinal oxygen saturation: Novel analysis method for the oxymap

Abstract

PURPOSE: To use a novel image analysis approach to consider how oxygen saturation changes as a function of vessel width and distance from the nerve and between superior and inferior retinal hemifields. METHODS: Ten images were acquired from one eye of 17 participants (mean [standard deviation] age, 28 [4] years; range, 22-38 years) using the Oxymap T1 retinal oximeter. Every pixel identified by the detection algorithm was extracted, and frequency histograms of retinal vessel oxygen saturation were plotted for each vessel diameter (70-170 μm). Histograms were fitted with two Gaussian models to identify peak arteriole and venule oxygen saturation. Mean (±standard error of the mean) arteriole a..